Inhibitors of PGHS-2Transactivator activity
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United States of America Patent
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Apr 19, 2011
Grant Date -
Dec 3, 2009
app pub date -
May 23, 2006
filing date -
May 23, 2005
priority date (Note) -
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Abstract
. PGHS-2 is an inducible gene product undetectable in most normal human tissues, but abundant in cancer cells. The present invention exploits a previously undisclosed transcriptional function of PGHS-2 distinct from its well-established enzymatic role to identify potential therapeutic agents useful in treating cancer. The method comprises a DNA binding assay in which PGHS-2 protein binding to the C/EBP, CRE and NF-κB regions of the PGHS-2 promoter in the presence and absence of test compounds is evaluated to identify inhibitors of PGHS-2 transactivation activity.
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