Crystal Structure of Human 70KD Ribosomal Protein S6 Kinase 1 Kinase Domain
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United States of America Patent
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Issued Date -
Dec 24, 2009
app pub date -
Jun 9, 2009
filing date -
Jun 20, 2008
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Abstract
Crystallization of the 70 kDa ribosomal protein S6 kinase polypeptide 1 (p70S6K1) kinase domain for X-ray crystallography analysis to generate the three-dimensional structure of the p70S6K1 kinase domain is described. Further described is the use of the three 5 dimensional structure of p70S6K1 kinase domain for identifying and designing ligands or low molecular weight molecules that specifically bind to and modulate (inhibit) the kinase activity of p70S6K1. These ligands or molecules can be used for the treatment of metabolic disorders such as diabetes and for the treatment of various cancers.
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