Immobilization of biological molecules onto surfaces coated with monolayers
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United States of America Patent
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Issued Date -
Dec 31, 2009
app pub date -
Apr 18, 2008
filing date -
Aug 27, 2001
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Abandoned
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Abstract
The present invention provides an article for immobilizing functional organic biomolecules through a covalent bond to a thiolate monolayer on a coinage metal surface. Also provided are methods for making the article and method for the immobilization of functional organic biomolecules on the article. The thiolate monolayer contains two moieties, one having an inert group that is resistant to reacting with biomolecules and one having a covalent bond forming group that reacts with the functional organic biomolecule to covalently immobilize it on the monolayer.
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