Negative regulation of NK cell functions by EAT-2, a sap-related adaptor expressed in innate immune cells
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United States of America Patent
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Issued Date -
Jan 21, 2010
app pub date -
May 15, 2006
filing date -
May 16, 2005
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Abandoned
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Abstract
The present invention relates to the identification EAT-2 and ERT as novel therapeutic targets for the modulation of innate immune cell functions. More particularly the present invention describes novel methods for modulating innate immune cells-mediated immune response, useful in the treatment of cancer, infectious diseases as well as autoimmune diseases. The invention also features EAT-2 deficient and overexpressing transgenic animals, screening assays to identify agents that modulate EAT-2 and ERT activity or expression as well as methods of treatments comprising a modulation of NK cells function
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