PRODUCTION AND RECOVERY OF POLYMERIC MICRO- AND NANOPARTICLES CONTAINING BIOACTIVE MACROMOLECULES
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United States of America Patent
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Issued Date -
Jan 28, 2010
app pub date -
May 9, 2007
filing date -
May 10, 2006
priority date (Note) -
Abandoned
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Abstract
The present invention describes a method to encapsulate bioactive macromolecules, as example but not limited for, peptidic drugs, into polymeric particles sizing less than 10 μm of diameter Particle production is based on emulsification/internal gelation procedure and comprises a formation of a water-in-oil emulsion followed by solubilization of dispersed insoluble calcium complex triggering gelation of said polymer dispersed in internal phase, by ionic cross-linking with free calcium ions. Finally, resulting gelled particles dispersed in the oil phase are recovered by partition phases coupled with high speed centrifugation cycles. In this case, the present invention describes a precise methodology to recover said gelled polymeric particles after particle production and includes an addition of acetate buffer solution at predetermined pH, dehydrating agents and residual oil dissolvent agent, at predetermined concentration, followed by high speed centrifugation cycles. This method of production and recovery was applied to the macromolecule, insulin, and demonstrated that the bioactivity of said peptidic drug was preserved.
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