PHARMACEUTICAL COMPOSITIONS CONTAINING HEPARIN DERIVATIVES
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United States of America Patent
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app pub date -
Mar 30, 2009
filing date -
Feb 29, 2008
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Abstract
An oral pharmaceutical composition for anticoagulation of blood includes a conjugate of an anticoagulation polysaccharide, such as heparin, covalently bonded to a hydrophobic agent wherein the conjugate is mixed with a solubilizer for inhibiting self-aggregation of the conjugate into nanoparticles. The composition can be coated, formed into tablets, or placed in capsules. Methods of making these oral formulations are also described.
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