Aqueous liquid preparation having improved intraocular gatifloxacin penetration
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United States of America Patent
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Issued Date -
Feb 11, 2010
app pub date -
Oct 11, 2007
filing date -
Oct 12, 2006
priority date (Note) -
Abandoned
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Abstract
An object is to provide an ophthalmic aqueous preparation excellent in the retention of gatifloxacin in a tear fluid and the preparation of gatifloxacin into an aqueous humor and a conjunctiva. Another object is to prevent the formation of any precipitate and the reduction in viscosity in the aqueous liquid preparation. An aqueous liquid preparation comprising gatifloxacin, a pharmacologically acceptable salt thereof or a hydrate of gatifloxacin or the salt and at least 0.15 w/v % of xanthan gum enables to improve the retention and penetration of gatifloxacin. When at least 0.2 w/v % of sodium chloride is added to the aqueous liquid preparation, the formation of any precipitate and the reduction in viscosity in the aqueous liquid preparation can be prevented.
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