SMALL MOLECULE INHIBITORS OF BACTERIAL DAM DNA METHYLTRANSFERASES
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United States of America Patent
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Issued Date -
Feb 11, 2010
app pub date -
Dec 6, 2005
filing date -
Dec 6, 2004
priority date (Note) -
Abandoned
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Abstract
Disclosed are compounds, crystal structures, data representations, methods of using, and methods of identifying compounds in relation to DNA methylation and inhibition of methylation. In embodiments, DNA methylation is by DNA-adenine methyltransferases (Dam). In an embodiment, compounds are used to treat a host suspected of infection by a pathogenic organism. In an embodiment, virulence of a pathogenic bacterium is modified by treatment with an agent capable of inhibiting a bacterial Dam enzyme. In an embodiment, compounds and methods are disclosed regarding Dam inhibitors.
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