Process for preparing a crystalline form of candesartan cilexetil
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United States of America Patent
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Issued Date -
Feb 18, 2010
app pub date -
Nov 22, 2007
filing date -
Nov 23, 2006
priority date (Note) -
Abandoned
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Abstract
A process for preparing a crystalline form of candesartan cilexetil referred to as Form I, which has a content of Form II lower than 1% (w/w), is described. The process includes a seeding stage with a crystalline product, which mainly includes Form I, and a digestion stage. The invention also relates to the crystalline form, the pharmaceutical compositions containing it and its use for the preparation of a medicament for the treatment of hypertension. Candesartan cilexetil Form I has shown good stability under accelerated stability conditions, when the content of Form II is lower than 1% w/w.
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