Amyloid-beta polypeptide vaccine

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 8871212
APP PUB NO 20100047262A1
SERIAL NO

12339841

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

Disclosed are novel methods and compositions for combating diseases characterized by deposition of amyloid. The methods generally rely on immunization against amyloid precursor protein (APP) or beta amyloid (Aβ). Immunization is preferably effected by administration of analogs of autologous APP or Aβ, said analogs being capable of inducing antibody production against the autologous amyloidogenic polypeptides. Especially preferred as an immunogen is autologous Aβ which has been modified by introduction of one single or a few foreign, immunodominant and promiscuous T-cell epitopes. Such methods and means include methods for the preparation of analogs and pharmaceutical formulations, as well as nucleic acid fragments, vectors, transformed cells, polypeptides and pharmaceutical formulations.

Loading the Abstract Image... loading....

First Claim

See full text

Family

Loading Family data... loading....

Patent Owner(s)

Patent OwnerAddressTotal Patents
H. LUNDBECK A/SVALBY-COPENHAGEN210

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Degan, Florence Dal Horsholm, DK 5 36
Jensen, Martin Roland Horsholm, DK 12 111
Koefoed, Peter Horsholm, DK 5 80
Nielsen, Klaus Gregorius Horsholm, DK 16 230
Rasmussen, Peter Birk Horsholm, DK 25 195

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (2)
5192688 Histological analysis method 10 1991
2004/0062,802 Maximizing effectiveness of substances used to improve health and well being 51 2003
 
BAVARIAN NORDIC, INC. (1)
2002/0090,379 INDUCING ANTIBODY RESPONSE AGAINST SELF-PROTEINS WITH THE AID OF FOREIGN T-CELL EPITOPES 15 1997
 
MINDSET BIOPHARMACEUTICALS, INC. (1)
2004/0091,945 Peptides and methods of screening immunogenic peptide vaccines against Alzheimer's Disease 9 2003
 
CORTECH, INC. (1)
5573916 Immunogenic constructs comprising b-cell and t-cell epitopes on common carrier 14 1994
 
GLAXOSMITHKLINE LLC (1)
5854204 A.beta. peptides that modulate .beta.-amyloid aggregation 114 1996
 
EPIMMUNE INC. (1)
5736142 Alteration of immune response using pan DR-binding peptides 84 1994
 
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (1)
4601903 Vaccine against Neisseria meningitidis Group B serotype 2 invasive disease 94 1985
 
The Scripps Research Institute (4)
4599230 Synthetic hepatitis B virus vaccine including both T cell and B cell determinants 124 1984
4599231 Synthetic hepatitis B virus vaccine including both T cell and B cell determinants 107 1984
5709995 Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses 27 1994
5780036 Peptides for inducing cytotoxic T lymphocyte responses to hepattis B virus 19 1995
 
PHARMEXA A/S (4)
6645500 Method for down-regulating osteoprotegerin ligand activity 15 1999
2003/0185,845 Novel immunogenic mimetics of multimer proteins 3 2002
2005/0163,744 Novel method for down-regulation of amyloid 12 2004
2005/0180,947 Novel application of vaccination against TNF-alpha 1 2004
 
HUNTINGTON POTTER (1)
5780587 Compounds and methods for inhibiting .beta.-protein filament formation and neurotoxicity 81 1995
 
SCHERING-PLOUGH ANIMAL HEALTH CORPORATION (1)
4608251 LHRH analogues useful in stimulating anti-LHRH antibodies and vaccines containing such analogues 95 1984
 
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (1)
5278056 Retroviral packaging cell lines and process of using same 47 1992
 
BAVARIAN NORDIC A/S (1)
2004/0141,958 Novel methods for therapeutic vaccination 40 2003
 
ALCON RESEARCH, LTD. (1)
5874469 Fluoroalkyl hydrocarbons for administering water insoluble or unstable drugs 9 1996
 
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (1)
5747323 Retroviral vectors comprising a VL30-derived psi region 3 1994
 
H. LUNDBECK A/S (5)
7135181 Method for down-regulation of amyloid 18 2001
2002/0187,157 Novel method for down-regulation of amyloid 15 2001
2003/0086,938 Novel methods for down-regulation of amyloid 32 2002
2003/0157,117 Novel method for down-regulation of amyloid 24 2002
2009/0092,579 NOVEL METHOD FOR DOWN-REGULATION OF AMYLOID 1 2008
 
SCIOS NOVA INC. (1)
5223482 Recombinant Alzheimer's protease inhibitory amyloid protein and method of use 31 1989
 
NEW YORK UNIVERSITY (2)
6713450 Synthetic immunogenic but non-amyloidogenic peptides homologous to amyloid .beta. for induction of an immune response to amyloid .beta. and amyloid deposits 52 2001
2002/0077,288 Synthetic immunogenic but non-amyloidogenic peptides homologous to amyloid beta for induction of an immune response to amyloid beta and amyloid deposits 11 2001
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (1)
4596792 Safe vaccine for hepatitis containing polymerized serum albumin 70 1984
 
Milkhaus Laboratory, Inc. (1)
5851996 Materials and methods for treatment of plaquing diseases 95 1998
 
BEALE STREET 143 INVEST APS (1)
7097837 Synthetic vaccine agents 25 2002
 
JANSSEN ALZHEIMER IMMUNOTHERAPY (6)
6787523 Prevention and treatment of amyloidogenic disease 81 1998
6761888 Passive immunization treatment of Alzheimer's disease 101 2000
6787144 Prevention and treatment of amyloidogenic disease 70 2000
6787637 N-Terminal amyloid-.beta. antibodies 87 2000
6875434 Methods of treatment of Alzheimer's disease 70 2000
6946135 Prevention and treatment of amyloidogenic disease 44 2004
 
UNIVERSITY OF WASHINGTON (1)
6340783 Rodent models of human amyloidoses 30 1996
 
MUSASHI ENGINEERING KABUSHIKI KAISHA (1)
4578770 Method of discriminating sheet 62 1983
 
TRUSTEES OF BOSTON UNIVERSITY (1)
5200339 Proteases causing abnormal degradation of amyloid .beta.-protein precursor 42 1991
 
United Biomedical, Inc. (1)
2003/0068,325 Immunogenic peptide composition for the prevention and treatment of Altzheimers Disease 12 2001
 
Pharnexa A/S (1)
2007/0041,945 NOVEL METHOD FOR DOWN-REGULATION OF AMYLOID 3 2006
 
SMITHKLINE BEECHAM BIOLOGICALS S.A. (1)
6544518 Vaccines 58 2000
 
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (1)
5589154 Methods for the prevention or treatment of vascular hemorrhaging and Alzheimer's disease 83 1994
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

  • No Forward Cites to Display

Maintenance Fees

Fee Large entity fee small entity fee micro entity fee due date
3.5 Year Payment $1600.00 $800.00 $400.00 Apr 28, 2018
7.5 Year Payment $3600.00 $1800.00 $900.00 Apr 28, 2022
11.5 Year Payment $7400.00 $3700.00 $1850.00 Apr 28, 2026
Fee Large entity fee small entity fee micro entity fee
Surcharge - 3.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 7.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00