Amyloid-beta polypeptide vaccine

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 8871212
APP PUB NO 20100047262A1
SERIAL NO

12339841

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Abstract

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Disclosed are novel methods and compositions for combating diseases characterized by deposition of amyloid. The methods generally rely on immunization against amyloid precursor protein (APP) or beta amyloid (Aβ). Immunization is preferably effected by administration of analogs of autologous APP or Aβ, said analogs being capable of inducing antibody production against the autologous amyloidogenic polypeptides. Especially preferred as an immunogen is autologous Aβ which has been modified by introduction of one single or a few foreign, immunodominant and promiscuous T-cell epitopes. Such methods and means include methods for the preparation of analogs and pharmaceutical formulations, as well as nucleic acid fragments, vectors, transformed cells, polypeptides and pharmaceutical formulations.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
H. LUNDBECK A/SVALBY-COPENHAGEN206

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Degan, Florence Dal Horsholm, DK 5 36
Jensen, Martin Roland Horsholm, DK 12 109
Koefoed, Peter Horsholm, DK 5 80
Nielsen, Klaus Gregorius Horsholm, DK 16 226
Rasmussen, Peter Birk Horsholm, DK 25 191

Cited Art Landscape

Patent Info (Count) # Cites Year
 
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* Cited By Examiner

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