US Patent Application No: 2010/0047,262

Number of patents in Portfolio can not be more than 2000

NOVEL METHOD FOR DOWN-REGULATION OF AMYLOID

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Abstract

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Disclosed are novel methods and compositions for combating diseases characterized by deposition of amyloid. The methods generally rely on immunization against amyloid precursor protein (APP) or beta amyloid (Aβ). Immunization is preferably effected by administration of analogues of autologous APP or Aβ, said analogues being capable of inducing antibody production against the autologous amyloidogenic polypeptides. Especially preferred as an immunogen is autologous Aβ which has been modified by introduction of one single or a few foreign, immunodominant and promiscuous T-cell epitopes. Such methods and means include methods for the preparation of analogues and pharmaceutical formulations, as well as nucleic acid fragments, vectors, transformed cells, polypeptides and pharmaceutical formulations.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
H. LUNDBECK A/SVALBY-COPENHAGEN364

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Degan, Florence Dal Horsholm, DK 4 17
Jensen, Martin Roland Holte, DK 13 51
Koefoed, Peter Horsholm, DK 6 29
Nielsen, Klaus Gregorius Søborg, DK 22 112
Rasmussen, Peter Birk Copenhagen, DK 27 104

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