Process for producing modified reconstituted sendai viral envelope specific for drug and/or gene delivery to liver cells
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United States of America Patent
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Issued Date -
Feb 25, 2010
app pub date -
Feb 24, 2006
filing date -
Apr 21, 2005
priority date (Note) -
Abandoned
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Abstract
A process for producing a targeted gene and/or drug delivery system for liver cells comprising the steps of: i. chemical reduction of Sendai virus for reduction of HN protein; ii. subjecting the reduced virus to the step of dialysis for removal of the reducing agent; iii. solubilizing the reduced virus with a detergent to obtain a solution; iv. centrifuging the solution to separate the insolubles consisting of reduced HN protein and core of said virus; v. adding histidylated lipid to the supernatant; vi. adding the drug or gene after addition of the lipid; vii. removing the detergent from the envelope and then subjecting it to the step of centrifugation to obtain His lipid F-virosomes with entrapped drug or DNA.
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