AMORPHOUS ROTIGOTINE TRANSDERMAL SYSTEM
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United States of America Patent
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Issued Date -
Apr 8, 2010
app pub date -
Oct 1, 2009
filing date -
Oct 6, 2008
priority date (Note) -
Abandoned
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Abstract
The present invention refers to a transdermal delivery device comprising a backing layer, an adhesive matrix layer comprising a supersaturated concentration of rotigotine substantially in amorphous form within the adhesive matrix, and a release liner. The present invention also refers to a method of preparing an adhesive matrix containing a supersaturated amount of rotigotine substantially in amorphous form. Further, the present invention refers to a method of stabilizing and a method of reestablishing the meta-stable amorphous-drug transdermal system during its manufacturing, storing, shipping and handling process.
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