NOVEL BENZAMIDE DERIVATIVES AND PROCESS FOR THE PREPARTION THEREOF

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United States of America Patent

APP PUB NO 20100105727A1
SERIAL NO

12531677

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention provides a novel benzamide derivative represented by formula 1 and an isomer, a pharmaceutically acceptable salt or hydrate thereof, and a composition for activating a 5-HT4 receptor comprising the same, as an active ingredient. Benzamide derivatives of the present invention has superior affinity for 5-HT4 receptors, capability to reduce the gastric evacuation time, capability to alleviate ventricular tachycardia, ventricular fibrillation, torsades de pointes and QT prolongation, and low toxicity. Therefore, benzamide derivatives of the present invention are therapeutically effective for digestive system diseases.

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Patent Owner(s)

Patent OwnerAddress
DONG-A PHARM CO LTDSEOUL 130-823

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Choi, Sun-Ho Seoul, KR 14 93
Choi, Sung-Hak Seongnam-si, KR 11 125
Im, Weon-Bin Yongin-si, KR 7 22
Kim, Eun-Jung Seoul, KR 67 1164
Kim, Ja-Young Seoul, KR 6 52
Park, Jung-Sang Suwon-si, KR 6 16
Rhee, Jae-Keol Suwon-si, KR 1 2
Shon, Ju-Hee Seoul, KR 1 2
Shon, Tae-Kyoung Seoul, KR 1 2
Sung, Hyun-Jung Suwon-si, KR 5 69
Yoo, Moo-Hi Seoul, KR 11 27

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