COMPOSITIONS AND METHODS FOR INHIBITING CANCER METASTASIS
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United States of America Patent
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Issued Date -
May 6, 2010
app pub date -
Mar 24, 2008
filing date -
Mar 22, 2007
priority date (Note) -
Abandoned
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Abstract
It has been discovered that antagonists of acetylated heat shock proteins can inhibit or reduce tumor cell invasion or metastasis. Compositions and methods for inhibiting tumor cell invasion or metastasis are provided. One embodiment provides a pharmaceutical composition including a heat shock protein antagonist in an amount effective to inhibit or reduce tumor cell invasion or metastasis. Another embodiment provides a pharmaceutical composition including a heat shock protein deacetylase in an amount effective to inhibit or reduce secretion of heat shock proteins. Representative target heat shock proteins include, but are not limited to hsp90α and hsp70. Methods of treating cancer or inhibiting tumor cell invasion and metastasis are also provided.
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