OXAZOLE AND THIAZOLE COMBINATORIAL LIBRARIES
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United States of America Patent
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app pub date -
Jan 8, 2010
filing date -
Mar 22, 1999
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Abstract
This invention provides a novel method for synthesizing an ensemble of peptides that allows for the generation of an unlimited number of antibiotic compounds. More specifically, the method comprises utilizes synthetic heterocyclic amino acids containing thaizole and/or oxazole as building blocks in a solid phase combinatorial synthesis to yield natural and unnatural antibiotic compounds.
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