Chemical linkers with single amino acids and conjugates thereof

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United States of America Patent

PATENT NO 8664407
APP PUB NO 20100113476A1
SERIAL NO

12528316

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Abstract

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The present disclosure provides drug-ligand conjugates that are potent cytotoxins and include a linker between the drug and ligand where the linker has a single amino acid. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.

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Patent Owner(s)

  • E. R. SQUIBB & SONS, L.L.C.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Liang Discovery Bay, US 852 8036
Gangwar, Sanjeev Foster City, US 90 1684
Guerlavais, Vincent Arlington, US 43 1530
Lonberg, Nils Woodside, US 99 12900
Zhang, Qian Danville, US 809 6806

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