Effectors of PAR-2 Activation and Their Use in the Modulation of Inflammation
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United States of America Patent
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Issued Date -
May 13, 2010
app pub date -
Jul 30, 2009
filing date -
Aug 5, 2008
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Abstract
The present invention relates to the recognition that PAR-2 receptors amplify the inflammatory response and that effectors of PAR-2 activation can thus be used to modulate the inflammatory response and thereby impart therapeutic benefit to patients. The invention is particularly directed to the use of PAR-2 effectors in the treatment of inflammation and nociception (pain) caused by inflammation, cancer and injury. The invention is particularly directed to negative effectors of PAR-2 activation, and more particularly to anti-PAR-2 antibodies that are negative effectors of PAR-2 activation.
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