DLL4 Signaling Inhibitors and Uses Thereof
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United States of America Patent
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Issued Date -
May 13, 2010
app pub date -
Jan 28, 2008
filing date -
Jan 26, 2007
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Abandoned
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Abstract
DLL4-binding antibodies, specifically antibodies preventing Notch signaling and internalization of DLL4, can: more efficiently than inhibitors only preventing DLL4-mediated Notch-signaling disrupt angiogenesis and pathological processes including tumor growth.
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