EXTRACELLULAR MATRIX MODULATING COATINGS FOR MEDICAL DEVICES
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United States of America Patent
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Issued Date -
May 13, 2010
app pub date -
Nov 5, 2009
filing date -
Nov 7, 2008
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Abandoned
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Abstract
A unique method and coatings are provided to promote/allow early stage tissue encapsulation/endothelization of medical devices while effectively controlling excessive tissue buildup by eluting antiproliferative therapeutic agent within a body of a patient. The method involves using a therapeutic agent that suppresses excessive extracellular matrix proliferation and allows/promotes thin tissue healing/encapsulation/endothelization of the device. Optimized timing of onset of elution to match onset of excessive extracellular matrix proliferation for maximum effectiveness is achieved by delay barrier with biochemical switch.
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