LIPOSOME DRUG CARRIERS WITH PH-SENSITIVITY
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United States of America Patent
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Issued Date -
May 27, 2010
app pub date -
Nov 24, 2008
filing date -
Nov 24, 2008
priority date (Note) -
Abandoned
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Abstract
Using liposomes to deliver bioactive agents to cancer or tumor cells and compositions of specific lipids that form liposomes to deliver a biologically active agent. A liposome composition for delivering of a biologically active agent, comprising liposomes comprising at a least first rigid lipid and a second rigid lipid each having a head group and a hydrophobic tail; a polyethyleneglycol-linked lipid having a side chain matching at least a portion of the first or the second lipid; and an entrapped biologically active agent. The first lipid can be a zwitterionic lipid and the second lipid can have a titratable head group. The composition can be adapted to release the entrapped at a certain pH.
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