METHOD FOR DETECTING THE BINDING BETWEEN MDM2 AND THE PROTEASOME
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United States of America Patent
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May 27, 2010
app pub date -
Apr 26, 2007
filing date -
Apr 26, 2007
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Abstract
This invention provides both nucleic acid and amino acid sequences encoding for isolated protein-HDM2 binding sites as well as for isolated protein-proteasome binding sites (the ED(X)Y sequences). In a further aspect this invention also provides related nucleic acids, amino acids, vectors, host cells, pharmaceutical compositions and articles of manufacture. This invention further provides methods for determining whether a test compound interacts with the binding between HDM2 and the proteasome, as well as pharmaceutical compositions comprising said test compound, in particular as anti-cancer agent, even more particular for treating cell proliferative disorders in a subject.
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