METHODS OF ENHANCING PROTEIN INCORPORATION INTO VIRUS LIKE PARTICLES
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United States of America Patent
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Issued Date -
Jun 10, 2010
app pub date -
Jun 27, 2007
filing date -
Jun 30, 2006
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Abandoned
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Abstract
The present invention comprises a method of increasing glycoprotein incorporation on the surface of VLPs, comprising expressing a nucleic acid encoding a chimeric glycoprotein in a host cell, wherein said chimeric glycoprotein comprises the transmembrane domain of an influenza hemagglutinin protein. The invention also embodies specific VLPs comprising said chimeric glycoproteins and methods of inducing immunity in an animal utilizing said VLPs.
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