METHOD FOR PREDICTING THE RESPONSE TO A THERAPY
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United States of America Patent
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Issued Date -
Jun 24, 2010
app pub date -
Nov 23, 2007
filing date -
Nov 24, 2006
priority date (Note) -
Abandoned
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Abstract
The present invention relates to cancer treatment and particularly to a method for predicting the response of a cancer subject to a given therapy. The invention provides a gene or gene product useful as a predictive marker for classifying the subjects. Also disclosed are diagnostic tools, test kits and compositions and their use in the method. The invention is based on the use of NAD(P)H:Quinone oxidoreductase 1, NQO1, which enables the identification and classification of subjects who would benefit from being excluded from a treatment, particularly from anthracycline-based adjuvant chemotherapy with epirubicin.
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