NOVEL ANTAGONISTS OF THE TOLL-LIKE RECEPTOR 4
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United States of America Patent
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Issued Date -
Jul 1, 2010
app pub date -
Oct 2, 2006
filing date -
Oct 2, 2006
priority date (Note) -
Abandoned
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Abstract
The present invention relates to a novel antagonist of the Toll-like receptor 4 (TLR-4). More specifically, the present invention relates to a lipopolysaccharide (LPS) isolated from the bacterium Bartonella quintana as a novel antagonist of the Toll-like receptor 4 (TLR-4). Further, the present invention relates to the use of said natural antagonist for the treatment of an autoimmune or inflammatory disease in a mammal and specifically for the treatment of rheumatoid arthritis (RA). Furthermore, the present invention relates to pharmaceutical compositions comprising a lipopolysaccharide (LPS) isolated from the bacterium Bartonella quintana.
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