OXINDOLE HYDRAZIDE MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS)

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United States of America Patent

SERIAL NO

12645952

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Abstract

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The present invention is related to the use of oxindole hydrazide derivatives of formula (I) for the treatment and/or prevention of metabolic disorders mediated by insulin resistance or hyperglycemia, comprising diabetes type I and/or II, inadequate glucose tolerance, insulin resistance, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, obesity, polycystic ovary syndrome (PCOS). In particular, the present invention is related to the use of oxindole hydrazide derivatives of formula (I) to modulate, notably to inhibit the activity of PTPs, in particular of PTP1B, TC-PTP, SHP and GLEPP-1. The present invention is furthermore related to novel oxindole hydrazide derivatives and method of preparation thereof.

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Patent Owner(s)

Patent OwnerAddress
APPLIED RESEARCH SYSTEMS ARS HOLDING N VJOHN GORSIRAWEG 14 CURACAO

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
BOMBRUN, Agnes Monnetier-Mornex, FR 43 422
Church, Dennis Commugny, CH 25 262
Gerber, Patrick Villars-sous-Yens, CH 17 63

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