Nanoparticulate probe for in vivo monitoring of tissue oxygenation

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United States of America Patent

PATENT NO 8568694
APP PUB NO 20100172843A1
SERIAL NO

12688767

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A new class of micro- and nano-particulate paramagnetic spin probes especially useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. Also provided are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods for measuring noninvasive methods of measuring oxygen concentration, oxygen partial pressure, oxygen metabolism, and nitric oxide concentration in a specific tissue, organ, or cell in vivo or in vitro.

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Patent Owner(s)

  • THE OHIO STATE UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kuppusamy, Periannan New Albany, US 10 34
Pandian, Ramasamy P Columbus, US 3 22
Parinandi, Narasimham L Upper Arlington, US 4 22
Zweier, Jay L Blacklick, US 7 52

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