Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor
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Apr 20, 2010
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Aug 11, 2005
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Abandoned
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Abstract
A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. One and two-dimensional gratings are also disclosed, including gratings characterized by unit cells with central posts, central holes, and two-level, two-dimensional gratings. A readout system for such sensors is also disclosed. Various applications for the biosensors are described, including cell-based assays for assessing the effect of drug compounds on cell function. A biosensor embodiment optimized for a luminescent response at two different wavelengths is also described. Such luminescent response could be produced by fluorescence (either native or from an attached fluorophore), phosphorescence, chemi-luminescence, or other luminescence technology. Two different luminescence technologies could be combined on the same biosensor chip.
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Patent Owner(s)
Patent Owner | Address | |
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X-BODY INC | 100 BEAVER STREET WALTHAM MA 02453 |
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Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
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Cunningham, Brian T | Champaign, US | 91 | 2622 |
Jogikalmath, Gangadhar | Cambridge, US | 54 | 576 |
Laing, Lance G | Belmont, US | 26 | 514 |
Li, Peter Y | Andover, US | 26 | 833 |
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Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |
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