ECTONUCLEOTIDASE INHIBITORS
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United States of America Patent
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Issued Date -
Aug 12, 2010
app pub date -
May 24, 2007
filing date -
May 24, 2006
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The present invention provides ectonucleotidase inhibitors represented by the following formula, including ecto-nucleotide triphosphate diphosphohydrolase (NTPDase) inhibitors and ecto-5′-nucleotidase (ecto-5′-NT) inhibitors, namely nucleotide mimetics as selective NTPDase or ecto-5′-NT inhibitors. It also provides methods for preparations of said compounds. Furthermore provided are pharmaceutical and diagnostic compositions comprising said compounds, and the use of said compounds in a medicament for treating diseases associated with ectonucleotidase activity and/or P1 or P2 receptors.
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