Amphiphilic molecule, molecular assembly comprising the amphiphilic molecule, and use of the molecular assembly

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United States of America Patent

PATENT NO 8241647
APP PUB NO 20100209458A1
SERIAL NO

12451555

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Abstract

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The present invention provides an amphiphilic molecule having a plurality of zwitterionic functional groups in its hydrophilic moiety and a molecular assembly comprising the amphiphilic molecule as a constituent lipid. The molecular assembly of the present invention forms a stable vesicular structure under a physiological pH environment to carry a substance of interest in the vesicular structure, and can release the substance of interest to the outside of the vesicular structure when it is deformed under an acidic pH environment. The molecular assembly of the present invention can be used as a carrier for a drug, a probe, a nucleic acid, a protein or the like.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
JCR PHARMACEUTICALS CO., LTD.HYOGO36
WASEDA UNIVERSITYTOKYO78

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ito, Manabu Tokyo, JP 42 6440
Mizuno, Atsushi Tokyo, JP 38 312
Nishiyama, Natsuko Tokyo, JP 1 0
Obata, Yosuke Tokyo, JP 5 7
Tajima, Shoji Tokyo, JP 6 38
Takeoka, Shinji Tokyo, JP 56 226
Takeuchi, Yoshito Tokyo, JP 1 0

Cited Art Landscape

Patent Info (Count) # Cites Year
 
JCR PHARMACEUTICALS CO., LTD. (1)
* 6965049 Zwitterionic lipid compound and uses thereof 4 2004
 
MARINA BIOTECH, INC. (1)
* 7939505 Amino acid lipids and uses thereof 3 2008
 
WASEDA UNIVERSITY (2)
6949663 Carboxylic acid-type lipid 5 2001
* 6933352 Amphiphilic compounds having a dendritic branch structure 3 2002
 
UNIVERSITY OF KANSAS (1)
* 5998482 Use of synthetic polycationic amphiphilic substances with fatty acid or hydrocarbon substituents as anti-sepsis agents 3 1998
* Cited By Examiner

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