Inhibitors of PDE4 and Methods of Use
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United States of America Patent
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Issued Date -
Aug 26, 2010
app pub date -
Aug 14, 2007
filing date -
Aug 14, 2006
priority date (Note) -
Abandoned
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Abstract
The inventors have succeeded in discovering that the p75 neurotrophin receptor (p75NTR) is directly involved in the degradation of cAMP via interaction of its intracellular domain with phosphodiesterase 4A4/5 (PDE4A4/5). Provided herein are methods and compositions for the treatment of conditions of PDE4A4/5 and p75NTR expression (such as pulmonary disease and nerve regeneration) by blocking the interaction of PDE4A4/5 and p75NTR, as well as methods for the screening of agents useful in such applications.
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