Triblock copolymers for cytoplasmic delivery of gene-based drugs

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United States of America Patent

PATENT NO 9505867
APP PUB NO 20100222407A1
SERIAL NO

11916252

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Abstract

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The invention features a triblock copolymer including a hydrophilic block; a hydrophobic block; and a positively charged block capable of reversibly complexing a negatively charged molecule, e.g., a nucleic acid, wherein the hydrophobic block is disposed between the hydrophilic block and the positively charged block. Desirably, the triblock copolymer is capable of self-assembling into a supramolecular structure, such as a micelle or vesicle. The invention further features methods of delivering negatively charged molecules and methods of treating a disease or condition using the polymers of the invention.

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Patent Owner(s)

  • ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE;ECOLE POLYTECHMIQUE FÉDÉRALE DE LAUSANNE

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hubbell, Jeffrey A Lausanne, CH 170 9225
Segura, Tatiana Los Angeles, US 24 166

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