Anti-ADDL monoclonal antibody and use thereof
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United States of America Patent
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Jan 31, 2012
Grant Date -
Sep 23, 2010
app pub date -
Jun 4, 2010
filing date -
Feb 14, 2005
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Abstract
The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLs, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.
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