Synthesis of 4-amino-thalidomide enantiomers
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United States of America Patent
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Apr 10, 2012
Grant Date -
Nov 4, 2010
app pub date -
Jul 16, 2010
filing date -
Nov 30, 2000
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Abstract
The invention provides new and useful analogs of 4-amino-thalidomide. These analogs include S(−)-4-amino-thalidomide and R(+)-4-amino-thalidomide. The invention also provides processes for making these analogs. Further, the invention provides methods for inhibiting angiogenesis and treating angiogenesis-associated diseases, including cancer and macular degeneration, by administering these compounds.
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