Molecules suitable for binding to a metal layer for covalently immobilizing biomolecules
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United States of America Patent
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Mar 27, 2012
Grant Date -
Nov 11, 2010
app pub date -
Jul 22, 2010
filing date -
Dec 16, 2005
priority date (Note) -
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Abstract
An article is provided for immobilizing functional organic biomolecules (e.g. proteins, DNA, and the like) through a covalent bond to a thiolate or disulfide monolayer to a metal surface wherein an extra activation step of the surface layer or an activation step of the functional biomolecules or bioreceptors could be avoided. The monolayer can contain, but is not limited to, two moieties. One has a group that resists nonspecific adsorption and another has a group that directly (without activation) reacts with functional groups on the biomolecules. In addition, poly(ethylene oxide) groups are incorporated in the monolayer surfaces to resist the nonspecific adsorption and to enhance the specific affinity interactions. A sensor device including these monolayers is also provided to perform reproducible, sensitive, specific and stable bioanalysis.
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