Methods of enhancing immune response using electroporation-assisted vaccination and boosting
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United States of America Patent
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Issued Date -
Nov 11, 2010
app pub date -
Nov 16, 2007
filing date -
Nov 17, 2006
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Abstract
Disclosed are methods of enhancing immune responses. Such methods involve the administration of vaccine compositions to different tissues to elicit an enhanced immune response. The enhanced response arises from the vaccination and boosting route of administration in two separate patient tissues, for example, by first administering a priming vaccination into skin and later administering a boost vaccination in muscle. In each case, priming and boosting, the administration of the vaccine composition is preferably carried out using contemporaneous electroporation-assisted delivery of the antigenic agent.
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