Orally Disintegrating Excipient
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United States of America Patent
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Issued Date -
Nov 11, 2010
app pub date -
May 11, 2009
filing date -
May 11, 2009
priority date (Note) -
Abandoned
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Abstract
The present invention is directed to coprocessed excipient particles comprising a cellulosic material such as microcrystalline cellulose in intimate association with silicon dioxide, a disintegrant and a polyol, sugar or a polyol/sugar blend. The excipient particles display good processing and are useful in prepared compressed solid dosage forms that exhibit rapid disintegration (less than about 60 seconds) when placed on the tongue or when tested according to USP disintegration testing, while still providing acceptable mouth feel.
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