DETECTION OF TISSUE ORIGIN OF CANCER
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United States of America Patent
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Issued Date -
Nov 11, 2010
app pub date -
Dec 29, 2006
filing date -
Dec 29, 2005
priority date (Note) -
Abandoned
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Abstract
Disclosed is a method for determining the cellular or tissue origin of tumor cells. The method entails determining the presence of at least one micro RNA (miRNA) in a sample derived from tumor tissue and based on the said determination establishing a miRNA expression profile and comparing this with pre-established miRNA expression profiles from cells, tissues or tumors. The determination uses short oligonucleotide probes comprising modified affinity-enhancing nucleobases.
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