Methods and compositions for inactivating glutamine synthetase gene expression
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United States of America Patent
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Jul 9, 2010
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Oct 29, 2008
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Abstract
Disclosed herein are methods and compositions for inactivating a glutamine synthetase (GS) gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
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