Hydrophobic polysaccharides with diester- or carbonate ester-containing linkages having enhanced degradation
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United States of America Patent
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Nov 19, 2013
Grant Date -
Dec 16, 2010
app pub date -
Jun 11, 2010
filing date -
Jun 11, 2009
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Abstract
Hydrophobic α(1→4)glucopyranose polymers with enhanced degradation properties are described. Between the α(1→4)glucopyranose polymeric portion and the hydrophobic portion exists a linker portion having a chemistry that facilitates degradation of the polymer. Diester and carbonate ester linker chemistries are exemplified. Biodegradable matrices can be formed from these polymers, and the matrices can be used for the preparation of implantable and injectable medical devices wherein the matrix is capable of degrading in vivo at an increased rate. Matrices including and capable of releasing a bioactive agent in vivo are also described.
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