Biomarkers for HPV-Induced Cancer

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United States of America Patent

APP PUB NO 20100316990A1
SERIAL NO

12745404

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Abstract

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Biomarkers that correlate with progression to neoplasia in human papillomavirus (HPV) induced cancer, for example cervical cancer have been identified. These biomarkers can be used to diagnosis or assist in the diagnosis of HPV-induced cancer. They can also be used to increase the positive predictive value of current screening modalities. In addition, they can provide insights into the biology of HPV-induced cancer and thus provide leads for the development of nonsurgical therapies. Exemplary biomarkers include cornulin, PA28 β, DJ-1, actin, transthyretin, HSPB1, CV intracellular channel 1, cytokeratin 8, transferrin, Hsρβ6 (HSP20), aflatoxin reductase, α2 type I collagen, creatine kinase B, cytokeratin 13 GST π, PA28 α, Manganese SOD, lamin A/C, serpin B1 (elastase inhibitor), serpin B3 (SCAA1), cytokeratin 10, cytokeratin 6A, and trp-tRNA synthetase. Preferred biomarkers for HPV-induced cancer include cornulin, DJ-1, PA28 α, and PA28 β, trp-tRNA synthetase, HSPβ6, creatine kinase B, aflatoxin reductase, GST π, transthyretin, transferrin, α2-type 1 collagen, and combinations thereof.

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Patent Owner(s)

Patent OwnerAddress
MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE INC1120 15TH STREET AUGUSTA GA 30912

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Arnouk, Hilal Birmingham, US 1 3
Dynan, William Martinez, US 1 3
Ferris, Daron Evans, US 1 3
Lee, Jeffrey Martinez, US 72 917
Merkley, Mark Augusta, US 1 3
Podolsky, Robert H Martinez, US 1 3
Stoppler, Hubert Foster City, US 1 3

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