Process for the preparation of oxidized phospholipids
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United States of America Patent
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Feb 28, 2012
Grant Date -
Dec 16, 2010
app pub date -
Aug 24, 2010
filing date -
Jul 9, 2004
priority date (Note) -
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Abstract
Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorous-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby.
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