CELL LINES EXPRESSING GABA RECEPTOR AND METHODS USING THEM
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United States of America Patent
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Jan 6, 2011
app pub date -
Feb 2, 2009
filing date -
Feb 1, 2008
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Abstract
The invention relates to Gamma-aminobutyric acid receptors (GABA receptors) as well as cells and cell lines stably expressing a GABA receptor. The invention includes cell lines that express various subunit combinations of GABA receptors. The GABA receptor- and GABA receptor subunit-expressing cell lines are highly sensitive, physiologically relevant and produce consistent results. The invention further provides methods of making such cells and cell lines. The GABA receptor- and GABA receptor subunit-expressing cells and cell lines provided herein are useful in identifying modulators of GABA receptors.
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