DESIGN AND SELECTION OF MEDICAMENTS THAT MODULATE THE FUNCTION AND ACTIVITY OF INTERLEUKIN 13
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United States of America Patent
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app pub date -
Dec 19, 2008
filing date -
Dec 21, 2007
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Abstract
The present invention relates generally to the field of medicaments in the form of therapeutic molecules including inflammatory modulators and their design and selection. More specifically, the present invention relates to a target site on Interleukin 13 (IL-13) by which a GAG molecule or polyanionic glycoconjugate or anionic polysaccharide modulates IL-13 activity or function, said target site selected from the list consisting of amino acids located in the AB loops and/or helix D of human IL-13 or its homolog or derivative, and the use of said IL-13 target site to design a medicament for modulating physiological processes. Therapeutic and prophylactic compositions comprising the designed medicaments are also contemplated.
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