METHOD FOR PERFORMING PROGNOSIS FOR HIGH-RISK BREAST CANCER PATIENTS USING TOP2A GENE ABERRATIONS
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United States of America Patent
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Issued Date -
Feb 3, 2011
app pub date -
Mar 30, 2007
filing date -
Apr 1, 2006
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Abandoned
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Abstract
A first exemplary method for performing a prognosis for a breast cancer patient, comprises the steps of determining the status of an aberration of the TOP2A gene in a tissue sample taken from the patient; and estimating the probability of either recurrence-free survival or of overall survival of the patient at a later time based upon a pre determined Hazard Ratio corresponding to the determined status. A second such exemplary method comprises the steps of determining the status of an aberration of the TOP2A gene in a tissue sample taken from the patient; and estimating the probability of either recurrence-free survival or of overall survival of the patient at a later time based upon a pre-determined Kaplan-Meier plot corresponding to the determined status.
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