STABILIZED PICOPLATIN ORAL DOSAGE FORM
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United States of America Patent
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Issued Date -
Feb 10, 2011
app pub date -
Aug 5, 2009
filing date -
Aug 5, 2009
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The invention provides an oral dosage form for the anti-cancer drug picoplatin comprising a core and a coating, the dosage form being free of redox-active metal salts. The core of the tablet is a substantially dry powder comprising about 10 to 60 wt % picoplatin wherein the picoplatin is a particulate of less than about 10 microns average particle diameter, about 40-80 wt % of a filler comprising a substantially water-soluble, water-dispersible, or water-absorbing carbohydrate, and an effective amount of up to about 5 wt % of a lubricant. The dosage form can further include a dispersant.
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