Pharmaceutical formulation comprising a water-insoluble active agent

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United States of America Patent

PATENT NO 8668934
APP PUB NO 20110070309A1
SERIAL NO

12953259

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A method of preparing a pharmaceutical formulation comprises providing a solution comprising a first solvent, a second solvent, an active agent, and an excipient. The second solvent is less polar than the first solvent and the excipient is more soluble in water than the active agent. The first and second solvents are removed from the solution to produce particles comprising the active agent and the excipient. In one version, the excipient comprises an amino acid and/or a phospholipid. A pharmaceutical formulation made by a version of the invention comprises particles comprising an active agent and an excipient which at least partially encapsulates the active agent, wherein the excipient is more soluble in water than the active agent.

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Patent Owner(s)

Patent OwnerAddress
NOVARTIS AGSWITZERLAND SENNWALD ST GALLEN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lechuga-Ballesteros, David San Jose, US 49 589
Miller, Danforth P San Carlos, US 5 25
Vehring, Reinhard Belmont, US 27 187

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