LIPID ENCAPSULATED DICER-SUBSTRATE INTERFERING RNA

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United States of America Patent

APP PUB NO 20110071208A1
SERIAL NO

12794701

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention provides novel, stable nucleic acid-lipid particles comprising one or more Dicer-substrate dsRNAs and/or small hairpin RNAs (shRNAs), methods of making the particles, and methods of delivering and/or administering the particles (e.g., for the treatment of a disease or disorder). In some embodiments, the nucleic acid-lipid particles of the invention comprise Dicer-substrate dsRNAs and/or shRNAs. In other embodiments, the nucleic acid-lipid particles of the invention comprise Dicer-substrate dsRNAs and/or shRNAs in combination with one or more additional interfering RNAs (e.g., siRNA, aiRNA, and/or miRNA). In further embodiments, the Dicer-substrate dsRNAs and/or shRNAs present in the nucleic acid-lipid particles of the invention are chemically synthesized.

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Patent Owner(s)

Patent OwnerAddress
PROTIVA BIOTHERAPEUTICS INCBURNABY BRITISH COLUMBIA V5J 5J8

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Judge, Adam Vancouver, CA 42 2288
MacLachlan, Ian Mission, CA 90 7658
Robbins, Marjorie Vancouver, CA 9 444

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