CARD-DOMAIN CONTAINING POLYPEPTIDES, ENCODING NUCLEIC ACIDS, AND METHODS OF USE

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United States of America Patent

SERIAL NO

12917295

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Abstract

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The invention provides caspase recruitment domain (CARD)-containing polypeptides and functional fragments thereof, encoding nucleic acid molecules, and specific antibodies. Also provided are screening methods for identifying CARD-associated polypeptides (CAPs), and for identifying agents that alter the association of a CARD-containing polypeptide with itself or with a CAP. Further provided are methods of altering a biochemical process modulated by a CARD-containing polypeptide, and methods of diagnosing a pathology characterized by an increased or decreased level of a CARD-containing polypeptide.

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Patent Owner(s)

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SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTELA JOLLA CA 92037

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Godzik, Adam San Diego, US 29 113
Pawlowski, Krzysztof Malmo, SE 12 61
Reed, John C Rancho Sante Fe, US 148 1282

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