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United States of America Patent

PATENT NO 8518674
APP PUB NO 20110086919A1
SERIAL NO

12893469

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Engineered strains of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 25% eicosapentaenoic acid (EPA, an ω-3 polyunsaturated fatty acid) in the total oil fraction are described. These strains comprise various chimeric genes expressing heterologous desaturases, elongases and acyltransferases and optionally comprise various native desaturase and acyltransferase knockouts to enable synthesis and high accumulation of EPA. Production host cells are claimed, as are methods for producing EPA within said host cells.

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Patent Owner(s)

  • E. I. DU PONT DE NEMOURS AND COMPANY

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Damude, Howard Glenn Hockessin, US 92 1247
Gillies, Peter John Landenberg, US 10 454
Macool, Daniel Joseph Rutledge, US 16 452
Picataggio, Stephen K Solana Beach, US 41 1212
Pollak, Dana M Walters West Chester, US 15 283
Ragghianti, James John Bear, US 9 332
Xue, Zhixiong Chadds Ford, US 65 1073
Yadav, Narendra S Wilmington, US 84 2506
Zhang, Hongxiang Chadds Ford, US 36 853
Zhu, Quinn Qun West Chester, US 133 1511

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