Isolation and use of solid tumor stem cells

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United States of America Patent

PATENT NO 8357491
APP PUB NO 20110092378A1
SERIAL NO

12979991

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Abstract

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A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise to both more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. Thus, solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell.

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Patent Owner(s)

  • THE REGENTS OF THE UNIVERSITY OF MICHIGAN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Al-Hajj, Muhammad Eagleville, US 21 1232
Clarke, Michael F Palo Alto, US 65 5898
Morrison, Sean J Ann Arbor, US 17 1066
Wicha, Max S Ann Arbor, US 31 1594

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